About the 2018 Symposium
The establishment and outcome of infections are defined by molecular interactions between the host and pathogen. Research and understanding of host-pathogen interactions have grown dramatically in a post-genomic era. As such, it is now recognized that the molecular events dictating pathogen colonization, host immune responses, pathology, and disease transmission are more complicated than simple ligand-receptor interfaces between macromolecules. The wealth of transcriptomics, proteomics and metabolomics data generated for a wide range of infectious diseases reveal that small molecule metabolism is an integral part of disease progression. This includes manipulation of host metabolic processes by pathogens; pathogen metabolic adaptation to the hosts’ environments; and interspecies communication and signaling via small molecules; as well as the emergence of immunometabolism as a key aspect of host responses that lead to protection or pathogenesis.
This symposium will bring together scientists representing a breadth of infectious diseases and immunology research, with a collective interest in studying the metabolism of pathogens and their hosts. The goals are to: 1) provide a current and comprehensive understanding of the role of metabolism in infectious diseases; 2) highlight emerging technologies and approaches important for studying infectious disease metabolism; 3) understand how information and knowledge gained through the study of metabolism can be translated into interventions to prevent or control infectious disease; and 4) create an opportunity for the formulation of new hypotheses and collaborations.
Specific topics that will be addressed:
- The role of immunometabolism in infectious diseases
- Pathogen and host interactions leading to adaptation of metabolic states and processes
- Communication and signaling via small molecule metabolites
- Emerging technologies and translation